| Pos | Club | PJ | G | E | P | GF | GC | DG | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Nashville SC | 31 | 21 | 7 | 3 | 66 | 23 | +43 | 70 |
| 2 |  Vancouver Whitecaps | 31 | 16 | 7 | 8 | 63 | 32 | +31 | 55 |
| 3 |  Inter Miami | 31 | 15 | 10 | 6 | 73 | 53 | +20 | 55 |
| 4 |  New England Revolution | 31 | 17 | 4 | 10 | 51 | 42 | +9 | 55 |
| 5 |  FC Dallas | 31 | 15 | 9 | 7 | 58 | 47 | +11 | 54 |
| 6 |  St. Louis City SC | 31 | 14 | 9 | 8 | 56 | 44 | +12 | 51 |
| 7 |  Chicago Fire | 31 | 15 | 6 | 10 | 55 | 46 | +9 | 51 |
| 8 |  San Jose Earthquakes | 31 | 13 | 9 | 9 | 52 | 45 | +7 | 48 |
| 9 |  Houston Dynamo | 31 | 13 | 9 | 9 | 41 | 39 | +2 | 48 |
| 10 |  Los Angeles FC | 32 | 12 | 11 | 9 | 50 | 35 | +15 | 47 |
| 11 |  Charlotte FC | 31 | 13 | 8 | 10 | 55 | 48 | +7 | 47 |
| 12 |  Philadelphia Union | 31 | 13 | 7 | 11 | 62 | 50 | +12 | 46 |
| 13 |  Seattle Sounders | 31 | 11 | 10 | 10 | 41 | 39 | +2 | 43 |
| 14 |  Colorado Rapids | 31 | 12 | 6 | 13 | 42 | 41 | +1 | 42 |
| 15 |  FC Cincinnati | 31 | 11 | 9 | 11 | 64 | 71 | -7 | 42 |
| 16 |  Orlando City | 31 | 12 | 6 | 13 | 60 | 72 | -12 | 42 |
| 17 |  LA Galaxy | 32 | 10 | 11 | 11 | 45 | 54 | -9 | 41 |
| 18 |  Real Salt Lake | 31 | 11 | 6 | 14 | 48 | 48 | 0 | 39 |
| 19 |  New York Red Bulls | 31 | 11 | 6 | 14 | 41 | 56 | -15 | 39 |
| 20 |  Columbus Crew | 31 | 11 | 5 | 15 | 50 | 49 | +1 | 38 |
| 21 |  Portland Timbers | 31 | 10 | 7 | 14 | 54 | 58 | -4 | 37 |
| 22 |  Toronto FC | 31 | 8 | 12 | 11 | 48 | 59 | -11 | 36 |
| 23 |  New York City FC | 31 | 8 | 11 | 12 | 45 | 43 | +2 | 35 |
| 24 |  San Diego FC | 31 | 8 | 11 | 12 | 55 | 58 | -3 | 35 |
| 25 |  Minnesota United | 31 | 8 | 11 | 12 | 47 | 55 | -8 | 35 |
| 26 |  Austin FC | 31 | 8 | 10 | 13 | 40 | 57 | -17 | 34 |
| 27 |  DC United | 31 | 7 | 12 | 12 | 38 | 55 | -17 | 33 |
| 28 |  Atlanta United | 31 | 8 | 6 | 17 | 39 | 54 | -15 | 30 |
| 29 |  CF Montréal | 31 | 6 | 7 | 18 | 36 | 62 | -26 | 25 |
| 30 |  Sporting Kansas City | 31 | 6 | 4 | 21 | 37 | 77 | -40 | 22 |
Partidos de la Jornada 27
Hora:
Philadelphia Union
4 - 2
Final
Orlando City
Atlanta United
2 - 2
Final
New York City FC
CF Montréal
3 - 1
Final
FC Cincinnati
Charlotte FC
0 - 1
Final
Chicago Fire
FC Dallas
1 - 0
Final
Los Angeles FC
Seattle Sounders
3 - 1
Final
Minnesota United
Nashville SC
2 - 0
Final
Toronto FC
Austin FC
3 - 3
Final
San Diego FC
Houston Dynamo
0 - 2
Final
Sporting Kansas City
Real Salt Lake
3 - 0
Final
New England Revolution
LA Galaxy
3 - 2
Final
Colorado Rapids
Vancouver Whitecaps
3 - 3
Final
DC United
San Jose Earthquakes
3 - 1
Final
Portland Timbers
Columbus Crew
2 - 1
Final
Inter Miami
New York Red Bulls
0 - 3
Final
St. Louis City SC
Partidos de la Jornada 28
Chicago Fire
2 - 1
Final
New York City FC
Toronto FC
2 - 1
Final
CF Montréal
Inter Miami
4 - 0
Final
DC United
Atlanta United
1 - 3
Final
FC Cincinnati
Orlando City
3 - 2
Final
Columbus Crew
New England Revolution
0 - 3
Final
Seattle Sounders
Philadelphia Union
2 - 1
Final
Real Salt Lake
New York Red Bulls
4 - 1
Final
San Diego FC
Charlotte FC
3 - 2
Final
FC Dallas
Austin FC
1 - 4
Final
Nashville SC
Minnesota United
2 - 2
Final
Houston Dynamo
Sporting Kansas City
3 - 3
Final
Portland Timbers
Colorado Rapids
1 - 1
Final
San Jose Earthquakes
Los Angeles FC
1 - 1
Final
Vancouver Whitecaps
St. Louis City SC
6 - 2
Final
LA Galaxy